Water → HCID 70435019, compound

Participants

Reaction Steps

A solution of 29.6 g (0.096 mol) of 1-[3,3-di(ethoxycarbonyl)propyl]-1-methoxymethylbenzene (14, p=0) in 200 ml of THF is added slowly to a stirred suspension of 4.0 g of LAH in 300 ml of THF. The mixture is stirred 2 h at room temperature and then treated sequentially with 4 ml of water, 4 ml of 15% NaOH solution, and 12 ml of water. The mixture is filtered and the filtrate evaporated to a residue which is triturated with hexane to afford 1-[3,3-di(hydroxymethyl)propyl]-1-methoxymethylbenzene.

Provenance & Evidence