Water → HCID 70435019, compound

HRID 1982243Notes

Reaction equation

HRID 1982243 reaction equation
C([O:3][C:4]([CH:6]([C:18](OCC)=[O:19])[CH2:7][CH2:8][C:9]1([CH2:15][O:16][CH3:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH2:10]1)=O)C.[H-].[H-].[H-].[H-].[Li+].[Al+3].O.[OH-].[Na+]>C1COCC1>[OH:3][CH2:4][CH:6]([CH2:18][OH:19])[CH2:7][CH2:8][C:9]1([CH2:15][O:16][CH3:17])[CH:10]=[CH:11][CH:12]=[CH:13][CH2:14]1

Participants

6

Reactant 4

HCID 962Water2×HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 70435299HCID 70435299, compound

Product 1

HCID 70435019HCID 70435019, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 29.6 g (0.096 mol) of 1-[3,3-di(ethoxycarbonyl)propyl]-1-methoxymethylbenzene (14, p=0) in 200 ml of THF is added slowly to a stirred suspension of 4.0 g of LAH in 300 ml of THF. The mixture is stirred 2 h at room temperature and then treated sequentially with 4 ml of water, 4 ml of 15% NaOH solution, and 12 ml of water. The mixture is filtered and the filtrate evaporated to a residue which is triturated with hexane to afford 1-[3,3-di(hydroxymethyl)propyl]-1-methoxymethylbenzene.

Workup

  1. filtrationThe mixture is filtered
  2. customthe filtrate evaporated to a residue which
  3. customis triturated with hexane

Sources & evidence

ORD record
ord-163e1750005f4945b028168d29dbb9da
Source dataset
uspto-grants-1986_06
Patent number
US04595690

Reaction notes

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