Hydrochloric Acid → HCID 20197561, compound

HRID 1982252Notes

Reaction equation

HRID 1982252 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH3:38])=[C:5]([C:21]([O:23][CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29](OCC(OC)=O)=[CH:28][CH:27]=2)=[O:22])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[C:7]=1[C:8]([O:10][CH3:11])=[O:9].[OH-:39].[Na+].[CH3:41][OH:42].[ClH:43]>O>[ClH:43].[CH3:1][C:2]1[NH:3][C:4]([CH3:38])=[C:5]([C:21]([O:23][CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29]([N:3]([CH2:4][CH2:41][OH:42])[CH2:2][CH2:1][OH:39])=[CH:28][CH:27]=2)=[O:22])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 20197438HCID 20197438, compound

Product 1

HCID 20197561HCID 20197561, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 0.5 g of 2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-5-[2-(4-methoxycarbonylmethoxyphenyl)ethoxycarbonyl]-1,4-dihydropyridine, 0.5 ml 10% aqueous NaOH, and 20 ml of methanol was heated on a steam bath for 20 min. The mixture was diluted with water, acidified with HCl, and extracted with ethyl acetate. The ethyl acetate was dried and evaporated to yield 0.40 g of 2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-5-[2-(4-carboxymethylphenyl)ethoxycarbonyl]-1,4-dihydropyridine (1). Calculated for C26H26N2O9.0.5H2O: C-59.17, H-5.36, N-5.52.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate was dried
  3. customevaporated

Sources & evidence

ORD record
ord-790341183c1f4b93be323351a62e45ad
Source dataset
uspto-grants-1986_06
Patent number
US04595690

Reaction notes

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