Water → HCID 13848581, compound

HRID 1982265Notes

Reaction equation

HRID 1982265 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([Cl:9])[C:3]=1[O:10][CH2:11][CH:12]1[O:14][CH2:13]1.[OH-].[Na+].O>C(O)C>[OH:14][CH2:13][CH:12]1[CH2:11][O:10][C:3]2[C:4]([Cl:9])=[C:5]([Cl:8])[CH:6]=[CH:7][C:2]=2[O:1]1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13645892HCID 13645892, compound

Product 1

HCID 13848581HCID 13848581, compoundYield 99.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1.128 g of 1-hydroxy-2-(2,3-epoxypropyloxy)-3,4-dichlorobenzene dissolved in 10 ml of ethanol is added 4 ml of 2N sodium hydroxide. The mixture is heated at 80° C. for 5 minutes, to which water is then added and extracted with ether. The organic layer is washed with water, then dried and evaporated to give 1.120 g of the objective 3-hydroxymethyl-7,8-dichloro-1,4-benzodioxane (IIb) as an oil. Yield 99%.

Workup

  1. additionis then added
  2. extractionextracted with ether
  3. washThe organic layer is washed with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-711895d0326549d7806e1fb3aaf31050
Source dataset
uspto-grants-1986_06
Patent number
US04595767

Reaction notes

Loading…