Hydrogen Peroxide → HCID 12399039, compound

HRID 1982298Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:30]=[CH:29][CH:28]=[CH:27][C:4]=1[CH:5]([C:15]1[CH:23]=[CH:22][C:21]([N:24]([CH3:26])[CH3:25])=[CH:20][C:16]=1[C:17]([OH:19])=[O:18])[C:6]1[CH:11]=[CH:10][C:9]([N:12]([CH3:14])[CH3:13])=[CH:8][CH:7]=1.OO>>[CH3:1][O:2][C:3]1[CH:30]=[CH:29][CH:28]=[CH:27][C:4]=1[C:5]1([C:6]2[CH:7]=[CH:8][C:9]([N:12]([CH3:14])[CH3:13])=[CH:10][CH:11]=2)[C:15]2[C:16](=[CH:20][C:21]([N:24]([CH3:26])[CH3:25])=[CH:22][CH:23]=2)[C:17](=[O:19])[O:18]1

Participants

Reactant 2

HCID 784Hydrogen Peroxide

HCID 12399029HCID 12399029, compound

Product 1

HCID 12399039HCID 12399039, compoundYield 17.3%

Procedure

Employing a procedure similar to that described in Example 27, part B above, 6.1 g of 2-(2-methoxy-4'-dimethylaminobenzhydryl)-5-dimethylaminobenzoic acid was oxidized with hydrogen peroxide to obtain 1.05 g of 3-(2-methoxyphenyl)-3-(4-dimethylaminophenyl)-6-dimethylaminophthalide (Formula I: R=CH3 ; X=H; Y=2-CH3OC6H4 ; Z=4-(CH3)2NC6H4), a light yellow-colored solid which melted at 215°-216° C.

Sources & evidence

ORD record: ord-e7bce3538ba543ed91d32ceeecfd6e08
Source dataset: uspto-grants-1986_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04595768

Reaction notes

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