HRID1982301

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID280

Carbon dioxide

CO2

结构：COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(C)C

HCID131714720

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@@H](N)CC(C)C)C(C)C

HCID131714719

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

850 mg of Z-Sta-Val-Tyr-Lys(Boc)-OMe are dissolved in 17 ml of 95% strength MeOH and hydrogenated with 85 mg of Pd-on-carbon with CO2 -absorption until saturation (approximately 1 hour). The catalyst is filtered off, the filtrate is concentrated to dryness and dried in a high vacuum at 40° yielding H-Sta-Val-Tyr-Lys(Boc)-OMe in the form of an amorphous powder; Rf (E)=0.58; Rf (H)=0.50. The resulting product is further reacted in stage 1.10.

WORKUP

后处理

filtrationThe catalyst is filtered off
concentrationthe filtrate is concentrated to dryness
customdried in a high vacuum at 40°

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-57c5490ac4d4462e8d97d7c2240651ba
来源数据集: uspto-grants-1986_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04595677
来源说明: uspto-grants-1986_06

反应 SMILES

[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C@H:7]([CH2:9][C:10]([NH:12][C@H:13]([C:17]([NH:19][C@H:20]([C:29]([NH:31][C@H:32]([C:45]([O:47][CH3:48])=[O:46])[CH2:33][CH2:34][CH2:35][CH2:36][NH:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])=[O:30])[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)=[O:18])[CH:14]([CH3:16])[CH3:15])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].C(=O)=O>CO>[NH2:1][C@H:2]([C@H:7]([CH2:9][C:10]([NH:12][C@H:13]([C:17]([NH:19][C@H:20]([C:29]([NH:31][C@H:32]([C:45]([O:47][CH3:48])=[O:46])[CH2:33][CH2:34][CH2:35][CH2:36][NH:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])=[O:30])[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)=[O:18])[CH:14]([CH3:15])[CH3:16])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5]