Carbon Dioxide → H-Sta-Val-Tyr-Lys(Boc)-OMe

Participants

Reaction Steps

850 mg of Z-Sta-Val-Tyr-Lys(Boc)-OMe are dissolved in 17 ml of 95% strength MeOH and hydrogenated with 85 mg of Pd-on-carbon with CO2 -absorption until saturation (approximately 1 hour). The catalyst is filtered off, the filtrate is concentrated to dryness and dried in a high vacuum at 40° yielding H-Sta-Val-Tyr-Lys(Boc)-OMe in the form of an amorphous powder; Rf (E)=0.58; Rf (H)=0.50. The resulting product is further reacted in stage 1.10.

Provenance & Evidence