Carbon Dioxide → HCID 178501416, compound

HRID 1982314Notes

Reaction equation

HRID 1982314 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([N:12]1[CH2:41][CH2:40][CH2:39][C@H:13]1[C:14]([NH:16][C@H:17]([C:25]([NH:27][C@H:28]([C:35]([O:37][CH3:38])=[O:36])[CH2:29][C:30]1[N:34]=[CH:33][NH:32][CH:31]=1)=[O:26])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].C(=O)=O>CO>[NH2:1][C@H:2]([C:10]([N:12]1[CH2:41][CH2:40][CH2:39][C@H:13]1[C:14]([NH:16][C@H:17]([C:25]([NH:27][C@H:28]([C:35]([O:37][CH3:38])=[O:36])[CH2:29][C:30]1[N:34]=[CH:33][NH:32][CH:31]=1)=[O:26])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

Participants

4

Reactant 2

HCID 280Carbon DioxideHCID 178501415HCID 178501415, compound

Product 1

HCID 178501416HCID 178501416, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.5 g of Z-Arg-Pro-Phe-His-OMe are dissolved in 25 ml of 95% strength methanol and, after the addition of 250 mg of Pd-on-carbon, hydrogenated with CO2 -absorption until saturation. The catalyst is filtered off and the filtrate is concentrated to dryness, yielding H-Arg-Pro-Phe-His-OMe in the form of an amorphous powder; Rf (E)=0.05; Rf (C)=0.3.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated to dryness

Sources & evidence

ORD record
ord-ce36bbe582574e5c89490fc7f30fdfdb
Source dataset
uspto-grants-1986_06
Patent number
US04595677

Reaction notes

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