HRID1982314

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID280

Carbon dioxide

CO2

结构：COC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)OCc1ccccc1

HCID178501415

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N

HCID178501416

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

2.5 g of Z-Arg-Pro-Phe-His-OMe are dissolved in 25 ml of 95% strength methanol and, after the addition of 250 mg of Pd-on-carbon, hydrogenated with CO2 -absorption until saturation. The catalyst is filtered off and the filtrate is concentrated to dryness, yielding H-Arg-Pro-Phe-His-OMe in the form of an amorphous powder; Rf (E)=0.05; Rf (C)=0.3.

WORKUP

后处理

filtrationThe catalyst is filtered off
concentrationthe filtrate is concentrated to dryness

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ce36bbe582574e5c89490fc7f30fdfdb
来源数据集: uspto-grants-1986_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04595677
来源说明: uspto-grants-1986_06

反应 SMILES

[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([N:12]1[CH2:41][CH2:40][CH2:39][C@H:13]1[C:14]([NH:16][C@H:17]([C:25]([NH:27][C@H:28]([C:35]([O:37][CH3:38])=[O:36])[CH2:29][C:30]1[N:34]=[CH:33][NH:32][CH:31]=1)=[O:26])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].C(=O)=O>CO>[NH2:1][C@H:2]([C:10]([N:12]1[CH2:41][CH2:40][CH2:39][C@H:13]1[C:14]([NH:16][C@H:17]([C:25]([NH:27][C@H:28]([C:35]([O:37][CH3:38])=[O:36])[CH2:29][C:30]1[N:34]=[CH:33][NH:32][CH:31]=1)=[O:26])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]