Hydrochloric Acid → Hydrochloric Acid

HRID 1982323Notes

Reaction equation

HRID 1982323 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C@H:7]([CH2:9][C:10]([O:12][CH3:13])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[ClH:24]>CO.[Pd]>[NH2:1][C@H:2]([C@H:7]([CH2:9][C:10]([O:12][CH3:13])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[ClH:24]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 14681745Z-Sta-OMe

Product 2

HCID 313Hydrochloric AcidHCID 13384495H-Sta-OMe

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

818 mg of Z-Sta-OMe dissolved in 40 ml of methanol are hydrogenated at room temperature and normal pressure in the presence of 190 mg of palladium-on-carbon catalyst (10% Pd) until saturation. During hydrogenation, the pH value is maintained constantly at 5 by the continuous addition of 0.5N HCl. After hydrogenation the catalyst is filtered off and the filtrate is concentrated by evaporation. H-Sta-OMe×HCl is obtained in the form of a colourless foam; Rf (G)=0.21. This crude product is used directly in stage 13.5.

Workup

  1. customare hydrogenated at room temperature
  2. filtrationAfter hydrogenation the catalyst is filtered off
  3. concentrationthe filtrate is concentrated by evaporation

Sources & evidence

ORD record
ord-f87b1843194a4ef3b0919d06a97d2a60
Source dataset
uspto-grants-1986_06
Patent number
US04595677

Reaction notes

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