HRID1982331

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID280

Carbon dioxide

CO2

结构：COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

HCID178501444

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(=O)C[C@H](O)[C@@H](N)CC(C)C

HCID178501445

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

380 mg of Z-Sta-Sar-His-Lys(Boc)-OMe in 10 ml of 95% strength MeOH are hydrogenated with CO2 -absorption until saturation after the addition of 100 mg of Pd-on-carbon (10% Pd), the solution is filtered and concentrated to dryness. After drying in a high vacuum, H-Sta-Sar-His-Lys(Boc)-OMe is obtained in the form of an amorphous powder; Rf (G)=0.18; Rf (E)=0.53.

WORKUP

后处理

filtrationthe solution is filtered
concentrationconcentrated to dryness
customAfter drying in a high vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4059eac6d71241bd88e4c86058aa1fea
来源数据集: uspto-grants-1986_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04595677
来源说明: uspto-grants-1986_06

反应 SMILES

[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C@H:7]([CH2:9][C:10]([N:12]([CH2:14][C:15]([NH:17][C@H:18]([C:25]([NH:27][C@H:28]([C:41]([O:43][CH3:44])=[O:42])[CH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])=[O:26])[CH2:19][C:20]1[N:24]=[CH:23][NH:22][CH:21]=1)=[O:16])[CH3:13])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].C(=O)=O>CO>[NH2:1][C@H:2]([C@H:7]([CH2:9][C:10]([N:12]([CH2:14][C:15]([NH:17][C@H:18]([C:25]([NH:27][C@H:28]([C:41]([O:43][CH3:44])=[O:42])[CH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:34]([O:36][C:37]([CH3:38])([CH3:39])[CH3:40])=[O:35])=[O:26])[CH2:19][C:20]1[N:24]=[CH:23][NH:22][CH:21]=1)=[O:16])[CH3:13])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5]