Carbon Dioxide → HCID 178501445, compound

HRID 1982331Notes

Reaction equation

HRID 1982331 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C@H:7]([CH2:9][C:10]([N:12]([CH2:14][C:15]([NH:17][C@H:18]([C:25]([NH:27][C@H:28]([C:41]([O:43][CH3:44])=[O:42])[CH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])=[O:26])[CH2:19][C:20]1[N:24]=[CH:23][NH:22][CH:21]=1)=[O:16])[CH3:13])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].C(=O)=O>CO>[NH2:1][C@H:2]([C@H:7]([CH2:9][C:10]([N:12]([CH2:14][C:15]([NH:17][C@H:18]([C:25]([NH:27][C@H:28]([C:41]([O:43][CH3:44])=[O:42])[CH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:34]([O:36][C:37]([CH3:38])([CH3:39])[CH3:40])=[O:35])=[O:26])[CH2:19][C:20]1[N:24]=[CH:23][NH:22][CH:21]=1)=[O:16])[CH3:13])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 280Carbon DioxideHCID 178501444Z-Sta-Sar-His-Lys(Boc)-OMe

Product 1

HCID 178501445HCID 178501445, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

380 mg of Z-Sta-Sar-His-Lys(Boc)-OMe in 10 ml of 95% strength MeOH are hydrogenated with CO2 -absorption until saturation after the addition of 100 mg of Pd-on-carbon (10% Pd), the solution is filtered and concentrated to dryness. After drying in a high vacuum, H-Sta-Sar-His-Lys(Boc)-OMe is obtained in the form of an amorphous powder; Rf (G)=0.18; Rf (E)=0.53.

Workup

  1. filtrationthe solution is filtered
  2. concentrationconcentrated to dryness
  3. customAfter drying in a high vacuum

Sources & evidence

ORD record
ord-4059eac6d71241bd88e4c86058aa1fea
Source dataset
uspto-grants-1986_06
Patent number
US04595677

Reaction notes

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