HCID 178514013, compound → HCID 178511197, compound

HRID 1982338Notes

Reaction equation

HRID 1982338 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[CH2:2][CH2:3][C:4]([NH:6][C@H:7]([C:14]([NH2:16])=[O:15])[CH2:8][C:9]1[N:13]=[CH:12][NH:11][CH:10]=1)=[O:5]>CO.O.[Pd]>[NH2:1][CH2:2][CH2:3][C:4]([NH:6][C@H:7]([C:14]([NH2:16])=[O:15])[CH2:8][C:9]1[N:13]=[CH:12][NH:11][CH:10]=1)=[O:5]

Participants

4

Reactant 1

HCID 178514013HCID 178514013, compound

Product 1

HCID 178511197HCID 178511197, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 22242641Methanol--water (1/1)Solvent

Procedure

8.19 g of Z-β-Ala-His-NH2 are hydrogenated at room temperature under normal pressure for 15 hours in 200 ml of methanol/water (95:5) with 0.82 g of palladium-on-carbon (5% Pd). After filtering off the catalyst, evaporating off the solvent and drying, H-β-Ala-His-NH2 is obtained in the form of a colourless powder; Rf (L)=0.01.

Workup

  1. filtrationAfter filtering off the catalyst
  2. customevaporating off the solvent
  3. customdrying

Sources & evidence

ORD record
ord-a7e0ffbbb2ba4304b63c6f27345bb5f0
Source dataset
uspto-grants-1986_06
Patent number
US04595677

Reaction notes

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