HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-(3-beta-Carbolinyl)acrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 9H-pyrido[3,4-b]indole-3-carbaldehyde | HCID 12789144 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(3-beta-Carbolinyl)acrylic acid | HCID 53930995 | 94.7% |
Reaction Steps
A mixture of 2.0 g of beta-carboline-3-carboxaldehyde, 2.0 g of malonic acid, 40 ml of water-free pyridine and 0.1 ml of piperidine is heated in a steam bath for 4 h. The solvent is evacuated in vacuum and after adding 20 ml of 2-propanol, the precipitate is filtered off. 2.3 g of 3-(3-beta-carbolinyl)-acrylic acid with a m.p. of 240°-260° C. (decomposition) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04596808 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-e85c08a1b8214665babd60ace6dc002a |
| Source note | uspto-grants-1986_06 |