反应详情

A mixture of 2.0 g of beta-carboline-3-carboxaldehyde, 2.0 g of malonic acid, 40 ml of water-free pyridine and 0.1 ml of piperidine is heated in a steam bath for 4 h. The solvent is evacuated in vacuum and after adding 20 ml of 2-propanol, the precipitate is filtered off. 2.3 g of 3-(3-beta-carbolinyl)-acrylic acid with a m.p. of 240°-260° C. (decomposition) is obtained.

1. temperatureis heated in a steam bath for 4 h
2. customThe solvent is evacuated in vacuum
3. additionafter adding 20 ml of 2-propanol
4. filtrationthe precipitate is filtered off