反应详情

A mixture of 2.3 g of 3-(3-beta-carbolinyl)-acrylic-acid, 70 ml of 99% ethanol, and 10 ml of concentrated sulfuric acid is boiled at the reflux for 5 h. After cooling, the reaction mixture is placed in an ice mixture of 100 g of ice and 40 ml of concentrated ammonium hydroxide. The reaction mixture is filtered off. 2.2 g of ethyl-3-(3-beta-carbolinyl)-acrylate with a m.p. of 132°-134° C. is obtained.

1. temperaturereflux for 5 h
2. temperatureAfter cooling
3. filtrationThe reaction mixture is filtered off