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HRID1982466

反应详情

EQUATION

反应方程式

HRID 1982466 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

2 次

结构：COC(=O)c1cccc2c1ccn2S(=O)(=O)c1ccc(C)cc1
HCID10947463

未命名化合物

结构：[Al+3].[H-].[H-].[H-].[H-].[Li+]
HCID21226445

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc(S(=O)(=O)n2ccc3c(CO)cccc32)cc1
HCID12553826

[1-(4-Methylbenzene-1-sulfonyl)-1H-indol-4-yl]methanol

C16H15NO3S

收率 87.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

The suspension of 1.9 g of lithium-aluminum hydride in 165 ml of tetrahydrofuran cooled to 0° C. is proportionately mixed with 16.45 g of 1-tosylindole-4-carboxylic-acid-methylester. After 30 minutes 1.9 ml of water, 1.9 ml of 15% soda lye and 5.7 ml of water are carefully and sequentially dripped in. After 20 minutes, the precipitate is filtered off, washed out with acetic-acid-ethylester and the filtrates are concentrated. The raw product (15.97 g) is crystallized out of diisopropylether. 13.15 g of 4-hydroxymethyl-1-tosylindole with a m.p. of 125°-126° C. is obtained.

WORKUP

后处理

  1. filtrationthe precipitate is filtered off
  2. washwashed out with acetic-acid-ethylester
  3. concentrationthe filtrates are concentrated
  4. customThe raw product (15.97 g) is crystallized out of diisopropylether