1-((4-Methoxyphenyl)methyl)piperazine → HCID 53740006, compound

HRID 1982501Notes

Reaction equation

HRID 1982501 reaction equation
O.[C:2]([O:6][C:7]([NH:9][C@H:10]([C:15]([OH:17])=O)[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])([CH3:5])([CH3:4])[CH3:3].[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:22][CH:21]=1.C1(C(C2C=CC=CC=2)N2CCN(C([C@@H](NC(=O)OC(C)(C)C)CC(C)C)=O)CC2)C=CC=CC=1>>[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][N:27]2[CH2:32][CH2:31][N:30]([C:15]([C@@H:10]([NH:9][C:7](=[O:8])[O:6][C:2]([CH3:3])([CH3:4])[CH3:5])[CH2:11][CH:12]([CH3:13])[CH3:14])=[O:17])[CH2:29][CH2:28]2)=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 2319051-((4-Methoxyphenyl)methyl)piperazineHCID 12373896N-Boc-L-Leucine HydrateHCID 13455629HCID 13455629, compound

Product 1

HCID 53740006HCID 53740006, compoundYield 95.5%

Procedure

Tert-butoxycarbonyl-L-leucine monohydrate (7.47 g) and 1-(4-methoxy-phenylmethyl)piperazine (6.18 g) were condensed in the same manner as employed in the preparation of tert-butyl (s)-1-(4-diphenylmethylpiperazine-1-yl carbonyl)-3-methylbutylcarbamate to yield 12.0 g of tert-butyl (s)-1-[4-(4-methoxyphenylmethyl)piperazine-1-yl carbonyl]-3-methylbutylcarbamate as a colorless amorphous substance (yield: 95%).

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-4cce8cf07da94e6ab3f34c2edbda4a39
Source dataset
uspto-grants-1986_06
Patent number
US04596803

Reaction notes

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