1-Ethylpiperazine → HCID 54036251, compound

HRID 1982504Notes

Reaction equation

HRID 1982504 reaction equation
O.C(OC(N[C@H](C(O)=O)CC(C)C)=O)(C)(C)C.C(N1CCNCC1)C.[C:26]1([CH:32](C2C=CC=CC=2)[N:33]2[CH2:38][CH2:37][N:36]([C:39]([C@@H:41]([NH:46][C:47](=[O:53])[O:48][C:49]([CH3:52])([CH3:51])[CH3:50])[CH2:42][CH:43]([CH3:45])[CH3:44])=[O:40])[CH2:35][CH2:34]2)C=CC=CC=1>>[CH2:32]([N:33]1[CH2:34][CH2:35][N:36]([C:39]([C@@H:41]([NH:46][C:47](=[O:53])[O:48][C:49]([CH3:50])([CH3:51])[CH3:52])[CH2:42][CH:43]([CH3:44])[CH3:45])=[O:40])[CH2:37][CH2:38]1)[CH3:26]

Participants

4

Reactant 3

HCID 791961-EthylpiperazineHCID 12373896N-Boc-L-Leucine HydrateHCID 13455629HCID 13455629, compound

Product 1

HCID 54036251HCID 54036251, compoundYield 65%

Procedure

Tert-butoxycarbonyl-L-leucine monohydrate (7.47 g) and 1-ethylpiperazine (3.42 g) were condensed in the same manner as employed in the preparation of tert-butyl (s)-1-(4-diphenylmethylpiperazine-1-yl carbonyl)-3-methylbutylcarbamate to yield 6.4 g of tert-butyl (s)-1-(4-ethylpiperazine-1-yl carbonyl)-3-methylbutylcarbamate as a colorless viscous liquid (yield: 65%).

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-a6153878311b4a3b990dc1d1bd5c8bb4
Source dataset
uspto-grants-1986_06
Patent number
US04596803

Reaction notes

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