HCID 22691111, compound → HCID 13455643, compound

HRID 1982509Notes

Reaction equation

HRID 1982509 reaction equation
[NH2:1][C@H:2]([C:7]([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:11][CH2:10]1)=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].CC(C)C[C@H](N[C:40]([C@@H:42]1[O:44][C@H:43]1[C:45]([O:47][CH2:48][CH3:49])=[O:46])=[O:41])C(N1CCN(C2C=CC=CN=2)CC1)=O>>[CH3:5][CH:4]([CH3:6])[CH2:3][C@H:2]([NH:1][C:40]([C@@H:42]1[O:44][C@H:43]1[C:45]([O:47][CH2:48][CH3:49])=[O:46])=[O:41])[C:7]([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[N:16]=[CH:17][CH:18]=[CH:19][N:20]=2)[CH2:11][CH2:10]1)=[O:8]

Participants

3

Reactant 2

HCID 22691111HCID 22691111, compoundHCID 86740005HCID 86740005, compound

Product 1

HCID 13455643HCID 13455643, compoundYield 92.1%

Procedure

Monoethyl trans-epoxy succinate (3.52 g) and 1-L-leucyl-4-(2-pyrimidinyl)piperazine (6.10 g) were condensed in the same manner as employed in the preparation of ethyl trans-3-[(s)-3-methyl-1-{4-(2-pyridyl)piperazine-1-yl carbonyl}butylcarbamoyl]oxirane-2-carboxylate to yield 8.50 g of ethyl trans-3-[(s)-3-methyl-1-{4-(2-pyrimidinyl)piperazine-1-yl carbonyl}butylcarbamoyl]oxirane-2-carboxylate (yield: 92.1%).

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-b93415a94a25424eb5ee3ffbe97589ec
Source dataset
uspto-grants-1986_06
Patent number
US04596803

Reaction notes

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