Hydrogen Peroxide → Isoquinoline, 3,4-dihydro-, 2-oxide

Temperature

0 °C

A magnetic stirrer was placed in a 300-ml eggplant-type flask, followed by an addition of sodium tungstate (0.33 g, 1.0 mmol). The internal atmosphere was replaced with nitrogen. Thereafter, methanol (200 ml) and 1,2,3,4-tetrahydroisoquinoline (6.65 g, 50.0 mmol) were added successively. To the resulting mixed solution, a 30% solution of hydrogen peroxide in water (17.0 g, 150.0 mmol) was added dropwise with stirring at 0° C. in the course of 30 minutes. After stirring the mixture at room temperature for 3 hours, the solvent was driven off under reduced pressures. The residue was taken up in methylene chloride (100 ml) and then washed twice with saturated saline (30 ml). The organic phase was separated and then dried with anhydrous magnesium sulfate. The solvent was driven off under reduced pressures, thereby obtaining an yellowish oily product. The oily product was subjected to silica gel column chromatography. The column as eluted with acetone to obtain 3,4-dihydroisoquinoline-2-oxide as a nitrone (6.54 g, 89 %).

1. customA magnetic stirrer was placed in a 300-ml eggplant-type flask
2. additionTo the resulting mixed solution
3. stirringAfter stirring the mixture at room temperature for 3 hours
4. washwashed twice with saturated saline (30 ml)
5. customThe organic phase was separated
6. dry with materialdried with anhydrous magnesium sulfate
7. customobtaining an yellowish oily product
8. washThe column as eluted with acetone

ORD record

ord-dbb5b92dc5744823acd4e989fe986b3f

Source dataset

uspto-grants-1986_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04596874