Imidazole → HCID 13764015, compound

HRID 1982532Notes

Reaction equation

HRID 1982532 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH:11]2[CH2:13][CH2:12]2)=O)=[CH:5][CH:4]=1.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:15]3[N:14]([CH:18]=[CH:17][N:16]=3)[CH:12]=[CH:13][CH:11]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 81580Methanone, cyclopropyl(4-methoxyphenyl)-

Product 1

HCID 13764015HCID 13764015, compound

Procedure

Combine 25 g (0.14 mol) of cyclopropyl 4-methoxyphenyl ketone with 50 g (0.73 mol) of imidazole, and heat to 200°-225° C. for 24 hr. Isolation from 200 g of silica gel using 2% methanol/methylene chloride followed by crystallization from methanol provides the title compound.

Workup

  1. customIsolation from 200 g of silica gel using 2% methanol/methylene chloride followed by crystallization from methanol

Sources & evidence

ORD record
ord-3dfc67400a2e4afe9c9c70d86d0df603
Source dataset
uspto-grants-1986_06
Patent number
US04596872

Reaction notes

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