Imidazole → HCID 23316950, compound

HRID 1982533Notes

Reaction equation

HRID 1982533 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([CH:9]2[CH2:11][CH2:10]2)=O)=[CH:3][CH:2]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[C:13]3[N:12]([CH:16]=[CH:15][N:14]=3)[CH:10]=[CH:11][CH:9]=2)=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 571501HCID 571501, compound

Product 1

HCID 23316950HCID 23316950, compound

Procedure

Combine 15 g (0.10 mol) of cyclopropyl 4-pyridinyl ketone with 30 g (0.44 mol) of imidazole and heat to 180°-200° C. for 24 hr. Isolation from 200 g silica gel using 5% methanol/methylene chloride followed by crystallization from ether provides the title compound.

Workup

  1. customIsolation from 200 g silica gel using 5% methanol/methylene chloride followed by crystallization from ether

Sources & evidence

ORD record
ord-efedabfea9194b4a83903557a53ef1e6
Source dataset
uspto-grants-1986_06
Patent number
US04596872

Reaction notes

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