Potassium Hydroxide → HCID 13810554, compound

HRID 1982534Notes

Reaction equation

HRID 1982534 reaction equation
[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]3[N:13]([CH:17]=[CH:18][N:19]=3)[CH2:14][CH2:15][CH:16]=2)=[CH:7][CH:6]=1)C(C)=O.[OH-].[K+]>CO.O>[NH2:1][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]3[N:13]([CH:17]=[CH:18][N:19]=3)[CH2:14][CH2:15][CH:16]=2)=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 23316956HCID 23316956, compound

Product 1

HCID 13810554HCID 13810554, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent2×

Procedure

5 g of the crude product from Example 8 is dissolved in 10 ml of methanol and added to a solution of 14 g of potassium hydroxide in 15 ml of methanol and 10 ml water. Heat to reflux for 2 hr. Cool to room temperature, and pour into 300 ml of water with good mixing. The resulting precipitate is recrystallized from ether to provide the title compound.

Workup

  1. temperatureHeat
  2. temperatureto reflux for 2 hr
  3. customThe resulting precipitate is recrystallized from ether

Sources & evidence

ORD record
ord-88d08d9122de40239b1586188f21df27
Source dataset
uspto-grants-1986_06
Patent number
US04596872

Reaction notes

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