Imidazole → HCID 13764019, compound

HRID 1982537Notes

Reaction equation

HRID 1982537 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10](F)=[CH:9][CH:8]=1)=O.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[N:14]1([C:10]2[CH:11]=[CH:12][C:7]([C:5]3[C:15]4[N:14]([CH:18]=[CH:17][N:16]=4)[CH2:2][CH2:3][CH:4]=3)=[CH:8][CH:9]=2)[CH:18]=[CH:17][N:16]=[CH:15]1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 197503-(4-Fluorobenzoyl)propyl chloride

Product 1

HCID 13764019HCID 13764019, compound

Procedure

Combine 50 g (0.25 mol) of 4-chloro-4'-fluorobutyrophenone with 120 g (1.76 mol) of imidazole, and heat to 175° C. for 18 hr. Isolation of the product from 500 g of silica gel, followed by crystallization from ethyl acetate, provides the title compound.

Workup

  1. customIsolation of the product from 500 g of silica gel, followed by crystallization from ethyl acetate

Sources & evidence

ORD record
ord-0476a2a9ebaa4b969d12233b1202efb6
Source dataset
uspto-grants-1986_06
Patent number
US04596872

Reaction notes

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