Imidazole → HCID 13764021, compound

HRID 1982542Notes

Reaction equation

HRID 1982542 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1)=O.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[CH3:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[C:15]3[N:14]([CH:18]=[CH:17][N:16]=3)[CH2:2][CH2:3][CH:4]=2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 987454-Chloro-4'-methylbutyrophenone

Product 1

HCID 13764021HCID 13764021, compound

Procedure

Combine 100 g (0.51 mole) of 4-chloro-4'-methylbutyrophenone with 300 g (4.4 mole) of imidazole and heat to 175° C. under nitrogen for 24 hr. Purification from 1 kg of silica gel using methylene chloride as solvent, followed by crystallization from ether provides the title compound.

Workup

  1. customPurification from 1 kg of silica gel
  2. customfollowed by crystallization from ether

Sources & evidence

ORD record
ord-6c0940217bbf4edeb083c55acd23ef30
Source dataset
uspto-grants-1986_06
Patent number
US04596872

Reaction notes

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