Hydrochloric Acid → HCID 131714757, compound

HRID 1982579Notes

Reaction equation

HRID 1982579 reaction equation
[ClH:1].Cl.[CH3:3][C:4]([O:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)([CH3:39])[CH2:5][O:6][C:7]([C:9]1[CH:18]([C:19]2[C:24]([F:25])=[C:23]([F:26])[C:22]([F:27])=[C:21]([F:28])[C:20]=2[F:29])[C:17]2[C:16](=[O:30])[CH2:15][N:14](CC3C=CC=CC=3)[CH2:13][C:12]=2[NH:11][C:10]=1[CH3:38])=[O:8]>CO>[ClH:1].[CH3:39][C:4]([O:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)([CH3:3])[CH2:5][O:6][C:7]([C:9]1[CH:18]([C:19]2[C:20]([F:29])=[C:21]([F:28])[C:22]([F:27])=[C:23]([F:26])[C:24]=2[F:25])[C:17]2[C:16](=[O:30])[CH2:15][NH:14][CH2:13][C:12]=2[NH:11][C:10]=1[CH3:38])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13669762HCID 13669762, compound

Product 1

HCID 131714757HCID 131714757, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The above hydrochloride (15 g), 400 ml of methanol, 10 ml of water, 8 ml of concentrated hydrochloric acid, and 1 g of 10% palladium on carbon were shaken with hydrogen (50 psig initial pressure) for 4.5 hours. The catalyst was separated and the filtrate was evaporated to dryness in vacuo. The residue was dissolved in methylene chloride and shaken with saturated sodium carbonate solution. The methylene chloride solution was separated and a precipitate formed after 20 minutes. The mixture was filtered to obtain 6.5 g of solid, m.p. 170°-3° C. The solid was dissolved in methanol and treated with hydrogen chloride to obtain 4.9 g of the title compound as the hydrochloride.

Sources & evidence

ORD record
ord-86f3f4f4d3ac48deb46c4cf20ae66be8
Source dataset
uspto-grants-1986_06
Patent number
US04596873

Reaction notes

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