Phenol → N-(2-phenoxyethyl)propionamide

HRID 1982584Notes

Reaction equation

HRID 1982584 reaction equation
[CH2:1]([C:3]1[O:4][CH2:5][CH2:6][N:7]=1)[CH3:2].[C:8]1([OH:14])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[O:14]([CH2:5][CH2:6][NH:7][C:3](=[O:4])[CH2:1][CH3:2])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 996PhenolHCID 664122-Ethyl-2-oxazoline

Product 1

HCID 13508823N-(2-phenoxyethyl)propionamideYield 90%

Procedure

Adding 2-ethyl-2-oxazoline to hot (150°) phenol and maintaining heating at about 175° for 16 additional hours. The oil is then quenched in water to give N-(2-phenoxyethyl)propionamide (IV) in approximately 90% yield.

Workup

  1. temperaturemaintaining
  2. temperatureheating at about 175° for 16 additional hours
  3. customThe oil is then quenched in water

Sources & evidence

ORD record
ord-9ec8c6e359054f9d832d0b0e4663c920
Source dataset
uspto-grants-1986_06
Patent number
US04596884

Reaction notes

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