Water → 3-Difluoromethoxy-benzyl 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropanecarboxylate

HRID 1982589Notes

Reaction equation

HRID 1982589 reaction equation
[F:1][CH:2]([F:12])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]Br.[CH3:13][C:14]1([CH3:24])[CH:16]([CH:17]=[C:18]([Cl:20])[Cl:19])[CH:15]1[C:21]([OH:23])=[O:22].[OH-].[K+].O>C1(C)C=CC=CC=1.[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH3:13][C:14]1([CH3:24])[CH:16]([CH:17]=[C:18]([Cl:20])[Cl:19])[CH:15]1[C:21]([O:23][CH2:7][C:6]1[CH:9]=[CH:10][CH:11]=[C:4]([O:3][CH:2]([F:12])[F:1])[CH:5]=1)=[O:22]

Participants

7

Reactant 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 91658Permethric acidHCID 27369993-(Difluoromethoxy)benzyl bromide

Product 1

HCID 233170343-Difluoromethoxy-benzyl 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropanecarboxylateYield 78%

Reagents, catalysts & solvents 2

HCID 74236Tetrabutylammonium BromideCatalystHCID 1140TolueneSolvent

Procedure

6.81 g (0.03 mol) of 3-difluoromethoxy-benzyl bromide and 6.27 g (0.03 mol) of 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropanecarboxylic acid were dissolved in 150 ml of toluene, 0.5 g of tetrabutylammonium bromide and 2 g of powdered KOH (industrial product, 87% pure) were added and the mixture was heated to the boil for 2-3 hours. After cooling, the reaction mixture was poured into 150 ml of water, the toluene phase was separated off, washed with 100 ml of water and dried with sodium sulphate and the toluene was distilled off in vacuo. Last residues of solvent were removed by incipient distillation at a bath temperature of 60°-80° C./0.2 to 1 mm Hg. 8.3 g (78% of theory) of 3-difluoromethoxy-benzyl 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropanecarboxylate were obtained as a viscous oil with the refractive index nD20 =1.5110.

Workup

  1. temperaturethe mixture was heated to the boil for 2-3 hours
  2. temperatureAfter cooling
  3. customthe toluene phase was separated off
  4. washwashed with 100 ml of water
  5. dry with materialdried with sodium sulphate
  6. distillationthe toluene was distilled off in vacuo
  7. customLast residues of solvent were removed by incipient distillation at a bath temperature of 60°-80° C./0.2 to 1 mm Hg

Sources & evidence

ORD record
ord-7b3fd8f7befa4fc28c58fdb68e869403
Source dataset
uspto-grants-1986_06
Patent number
US04596880

Reaction notes

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