Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl ester → Methyl 4-formamidopyridine-2-carboxylate

HRID 1982688Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1982688
C[C:2](OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=[O:3].[NH2:25][C:26]1[CH:31]=[CH:30][N:29]=[C:28]([C:32]([O:34][CH3:35])=[O:33])[CH:27]=1>C(O)=O>[CH:2]([NH:25][C:26]1[CH:31]=[CH:30][N:29]=[C:28]([C:32]([O:34][CH3:35])=[O:33])[CH:27]=1)=[O:3]

Komponenten

4

Edukt 2

HCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterHCID 3759117Methyl 4-aminopyridine-2-carboxylate

Produkt 1

HCID 13060165Methyl 4-formamidopyridine-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture of formic acid (20 g.) and acetic anhyride (41.3 g.) was stirred for 30 minutes at 50° C. and thereto was added methyl 4-amino-2-pyridinecarboxylate (11 g.) at ambient temperature, and then the mixture was stirred for 2 hours at 70°-75° C. After the removal of the solvent from the reaction mixture, the residue was recrystallized from ethanol (160 ml.) to give a pale yellow powder of methyl 4-formamido-2-pyridinecarboxylate (8.3 g.), mp. 185° to 186.5° C.

Aufarbeitung

  1. stirringthe mixture was stirred for 2 hours at 70°-75° C
  2. customAfter the removal of the solvent from the reaction mixture
  3. customthe residue was recrystallized from ethanol (160 ml.)

Quellen und Nachweise

ORD-Eintrag
ord-e39ad9ddaed94db6971f3645b54970b4
Quelldatensatz
uspto-grants-1986_06
Patentnummer
US04596869

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