Hydrochloric Acid → HCID 54097963, compound

HRID 1982696Notes

Reaction equation

HRID 1982696 reaction equation
C([NH:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10](=[N:16][O:17][CH3:18])[C:11]([O:13]CC)=[O:12])[N:5]=1)=O.[OH-].[Na+].Cl>C(O)C>[NH2:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10](=[N:16][O:17][CH3:18])[C:11]([OH:13])=[O:12])[N:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54343679HCID 54343679, compound

Product 1

HCID 54097963HCID 54097963, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl 2-(4-formamidopyrimidin-2-yl)-2-methoxyiminoacetate (4.3 g.) and 10N aqueous solution of sodium hydroxide (6.1 ml.) in ethanol (100 ml.) was stirred for 3 hours at ambient temperature. To the reaction mixture was gradually added concentrated hydrochloric acid with stirring, whereby said mixture was adjusted to pH 3. The precipitates were collected by filtration and washed successively with ethanol and diethyl ether and then dried to give white crystals of 2-(4-aminopyrimidin-2-yl)-2-methoxyiminoacetic acid.

Workup

  1. stirringwith stirring
  2. filtrationThe precipitates were collected by filtration
  3. washwashed successively with ethanol and diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-ddf42669deac4c2a9db1fe092e5c85cb
Source dataset
uspto-grants-1986_06
Patent number
US04596869

Reaction notes

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