反应详情

2.87 g 1-chloro-2-(4-ethynyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene are dissolved in 10 ml of ethyl acetate and 5 ml of ethanol. 0.3 g 10% palladium on carbon are added and the resultant mixture is stirred under hydrogen atmosphere (1 atm) overnight. The reaction mixture is filtered over Celite and the filtrate is concentrated. The residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0->5:1).

1. filtrationThe reaction mixture is filtered over Celite
2. concentrationthe filtrate is concentrated
3. customThe residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0->5:1)