4-(2-Benzyloxybenzyl)benzyl alcohol → 4-(2-Benzyloxybenzyl)benzaldehyde

HRID 1982811Notes

Reaction equation

HRID 1982811 reaction equation
[CH2:1]([O:8][C:9]1[CH:23]=[CH:22][CH:21]=[CH:20][C:10]=1[CH2:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][OH:17])=[CH:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClCCl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:8][C:9]1[CH:23]=[CH:22][CH:21]=[CH:20][C:10]=1[CH2:11][C:12]1[CH:13]=[CH:14][C:15]([CH:16]=[O:17])=[CH:18][CH:19]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 688722414-(2-Benzyloxybenzyl)benzyl alcohol

Product 1

HCID 219093044-(2-Benzyloxybenzyl)benzaldehydeYield 97.6%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(2-benzyloxybenzyl)benzyl alcohol (1.0 g) in dichloromethane (50 mL) was added manganese dioxide (10 g), and the mixture was stirred at room temperature for 3 hours. After insoluble materials were removed by filtration, the solvent of the filtrate was removed under reduced pressure to give 4-(2-benzyloxybenzyl)benzaldehyde (0.97 g).

Workup

  1. customAfter insoluble materials were removed by filtration
  2. customthe solvent of the filtrate was removed under reduced pressure

Sources & evidence

ORD record
ord-d6fec15306f945098762beb3c9d76b43
Source dataset
uspto-grants-2009_06
Patent number
US07541341B2

Reaction notes

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