反应详情

温度

130 °C

The mixture of 1.28 g of 3-t-butyl-1H-pyrazole, 0.66 g of paraformaldehyde and 0.3 g of triethylamine was stirred at 130° C. for 7 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The filterate was concentrated under reduced pressure. Hexane was added to the residue, and then crystalline was formed. The crystalline was collected to obtain 1.07 g of 3-t-butyl-1H-pyrazole-1-ylmethanol.

1. temperatureAfter the reaction mixture was cooled to room temperature
2. filtrationThe mixture was filtered
3. concentrationThe filterate was concentrated under reduced pressure
4. additionHexane was added to the residue
5. customcrystalline was formed
6. customThe crystalline was collected