Thionyl Chloride → 3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1982997Notes

Reaction equation

HRID 1982997 reaction equation
[C:1]([C:5]1[CH:9]=[CH:8][N:7]([CH2:10]O)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:14])=O>ClCCl>[ClH:14].[C:1]([C:5]1[CH:9]=[CH:8][N:7]([CH2:10][Cl:14])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 231492083-t-butyl-1H-pyrazole-1-ylmethanol

Product 1

HCID 231491523-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.07 g of 3-t-butyl-1H-pyrazole-1-ylmethanol was dissolved to 140 ml of dichloromethane. 2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.66 g of 3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-71f639c4cb5c455398ba3d9b56928875
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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