Formaldehyde → HCID 23149160, compound

HRID 1983001Notes

Reaction equation

HRID 1983001 reaction equation
[CH:1]([C:3]1[CH:7]=[CH:6][NH:5][N:4]=1)=[O:2].[CH2:8]=[O:9].C(N(CC)CC)C>CC(C)=O>[OH:9][CH2:8][N:5]1[CH:6]=[CH:7][C:3]([CH:1]=[O:2])=[N:4]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8471TriethylamineHCID 122183831H-Pyrazole-3-carbaldehyde

Product 1

HCID 23149160HCID 23149160, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
100 °C

Procedure

The mixture of 0.96 g of 3-formyl-1H-pyrazole, 0.60 g of paraformaldehyde and 0.3 ml of triethylamine was stirred at 100° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The filterate was concentrated under reduced pressure to obtain 1.21 g of 1-(hydroxymethyl)-3-formyl-1H-pyrazole. The crude product was used for next process without purification.

Workup

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationThe filterate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-57712720801f40079a3b45a31d053ec5
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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