Chlorosuccinimide → HCID 178441972, compound

HRID 1983013Notes

Reaction equation

HRID 1983013 reaction equation
[C:1]([C:5]1[CH:9]=[CH:8][NH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:10]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[C:1]([C:5]1[C:9]([Cl:10])=[CH:8][NH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 178441177HCID 178441177, compound

Product 1

HCID 178441972HCID 178441972, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1.42 g of 3-t-butyl-1H-pyrazole was dissolved to 230 ml of chloroform. 1.55 g of N-chlorosuccinimide was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure, and the residue was subjected to silica gel column chromatography to obtain 0.62 of 3-t-butyl-4-chloro-1H-pyrazole.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-222971459eaa4dde9bbdcb00872cb001
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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