Formaldehyde → 4-(Trifluoromethyl)-1H-pyrazole-1-methanol
Reaction equation
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:4]=[N:5][NH:6][CH:7]=1.[CH2:10]=[O:11]>CC(C)=O>[F:1][C:2]([F:9])([F:8])[C:3]1[CH:4]=[N:5][N:6]([CH2:10][OH:11])[CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 130 °C
Procedure
The mixture of 0.59 g of 4-(trifluoromethyl)-1H-pyrazole and 0.26 g of paraformaldehyde was stirred at 130° C. for 4 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The residue was concentration under reduced pressure to obtain 0.60 g of 4-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.
Workup
- temperatureAfter the reaction mixture was cooled to room temperature
- filtrationThe mixture was filtered
- concentrationconcentration under reduced pressure
Sources & evidence
- ORD record
- ord-f77e9e4b74ab44bf8ad91cda84084c59
- Source dataset
- uspto-grants-2009_06
- Patent number
- US07541374B2
Reaction notes
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