HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1983023Generated: November 2, 2026
Formaldehyde → 4-(Trifluoromethyl)-1H-pyrazole-1-methanol
https://huagongshe.com/reaction/1983023
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4-(Trifluoromethyl)-1H-pyrazole | HCID 12777795 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(Trifluoromethyl)-1H-pyrazole-1-methanol | HCID 23149167 | 83.3% |
Reaction Steps
The mixture of 0.59 g of 4-(trifluoromethyl)-1H-pyrazole and 0.26 g of paraformaldehyde was stirred at 130° C. for 4 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The residue was concentration under reduced pressure to obtain 0.60 g of 4-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07541374B2 |
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| Source dataset | uspto-grants-2009_06 |
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| ORD ID | ord-f77e9e4b74ab44bf8ad91cda84084c59 |
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| Source note | uspto-grants-2009_06 |
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