Thionyl Chloride → HCID 57712395, compound

HRID 1983028Notes

Reaction equation

HRID 1983028 reaction equation
O[CH2:2][N:3]1[CH:7]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:5]([C:13]([F:16])([F:15])[F:14])=[N:4]1.S(Cl)([Cl:19])=O>ClCCl>[Cl:19][CH2:2][N:3]1[CH:7]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:5]([C:13]([F:16])([F:15])[F:14])=[N:4]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 23149171HCID 23149171, compound

Product 1

HCID 57712395HCID 57712395, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.23 g of 1-(hydroxymethyl)-3-(trifluoromethyl)-4-ethyoxycarbonyl-1H-pyrazole was dissolved to 30 ml of dichloromethane. 1.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 2.38 g of 1-(chloromethyl)-3-(trifluoromethyl)-4-ethoxycarbonyl-1H-pyrazole.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-38cb5d145f924d069fa146fbc5744416
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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