Thionyl Chloride → HCID 23149161, compound

HRID 1983030Notes

Reaction equation

HRID 1983030 reaction equation
[CH:1]([C:4]1[N:8]=[CH:7][N:6]([CH2:9]O)[N:5]=1)([CH3:3])[CH3:2].S(Cl)([Cl:13])=O>ClCCl>[ClH:13].[Cl:13][CH2:9][N:6]1[CH:7]=[N:8][C:4]([CH:1]([CH3:3])[CH3:2])=[N:5]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 23149130HCID 23149130, compound

Product 1

HCID 23149161HCID 23149161, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.28 g of 3-i-propyl-1H-1,2,4-triazole1-ylmethanol was dissolved to 20 ml of dichloromethane, and 2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for 8 hours. The reaction mixture was concentrated under reduced pressure. Diethylether was added to the residue, as a result, a crystal was formed. The crystal was collected to obtain 1.58 g of 1-(chloromethyl)-3-i-propyl-1H-1,2,4-triazole hydrochloride.

Workup

  1. additionwas added to the solution
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. additionDiethylether was added to the residue, as a result
  4. customa crystal was formed
  5. customThe crystal was collected

Sources & evidence

ORD record
ord-2d24f31005b94b8ab5775b1be15accce
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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