Sodium Hydroxide → HCID 178441970, compound

HRID 1983033Notes

Reaction equation

HRID 1983033 reaction equation
[C:1]([C:5]1[N:9]=[CH:8][NH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].[Br:12]Br>O>[Br:12][C:8]1[NH:7][N:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[N:9]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24408BromineHCID 178441830HCID 178441830, compound

Product 1

HCID 178441970HCID 178441970, compoundYield 92.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

The mixture of 2.51 g of 3-t-butyl-1H-1,2,4-triazole, 35 ml of water and 2.5 ml of 50% aqueous solution of sodium hydroxide was cooled to 0° C., then 3.5 g of bromine was added to it. It was stirred at room temperature for 3 hours. The reaction mixture was extracted by ethyl acetate, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was recrystallized from hexane to obtain 3.80 g of 5-bromo-3-t-butyl-1H-1,2,4-triazole.

Workup

  1. extractionThe reaction mixture was extracted by ethyl acetate
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was recrystallized from hexane

Sources & evidence

ORD record
ord-c2800a8785ef4a76a403a1289fc514be
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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