Formaldehyde → HCID 23149129, compound

HRID 1983034Notes

Reaction equation

HRID 1983034 reaction equation
[Br:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:3]=1.[CH2:11]=[O:12].C(N(CC)CC)C>CC(C)=O>[Br:1][C:2]1[N:6]([CH2:11][OH:12])[N:5]=[C:4]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:3]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8471TriethylamineHCID 178441970HCID 178441970, compound

Product 1

HCID 23149129HCID 23149129, compoundYield 72.8%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
130 °C

Procedure

The mixture of 3.45 g of 5-bromo-3-t-butyl-1H-1,2,4-triazole, 0.61 g of paraformaldehyde and 0.17 g of triethylamine was stirred at 130 ° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered. Hexane was added to the residue and filtered. The filtrate was concentrated under reduced pressure to obtain 2.88 g of 5-bromo-3-t-butyl-1H-1,2,4-triazole1-ylmethanol.

Workup

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. additionHexane was added to the residue
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c46ec246e0184464a14d92215ac851e3
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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