Thionyl Chloride → 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

HRID 1983038Notes

Reaction equation

HRID 1983038 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[N:7]=[CH:6][N:5]([CH2:8]O)[N:4]=1.S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:8][N:5]1[CH:6]=[N:7][C:3]([C:2]([F:11])([F:10])[F:1])=[N:4]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 231491401-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

Product 1

HCID 231491371-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.52 g of 3-(trifluoromethyl)-1H-1,2,4-triazole 1-ylmethanol was dissolved to 50 ml of dichloromethane, and 2.7 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.36 g of 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole.

Workup

  1. additionwas added to the solution
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-78c4601423424f22baf8de452c249ad8
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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