HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole | HCID 23149140 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole | HCID 23149137 | — |
Reaction Steps
1.52 g of 3-(trifluoromethyl)-1H-1,2,4-triazole 1-ylmethanol was dissolved to 50 ml of dichloromethane, and 2.7 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.36 g of 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541374B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-78c4601423424f22baf8de452c249ad8 |
| Source note | uspto-grants-2009_06 |