Formaldehyde → 3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol
Reaction equation
[F:1][C:2]([F:12])([C:7]1[CH:11]=[CH:10][NH:9][N:8]=1)[C:3]([F:6])([F:5])[F:4].[CH2:13]=[O:14]>CC(C)=O>[F:12][C:2]([F:1])([C:7]1[CH:11]=[CH:10][N:9]([CH2:13][OH:14])[N:8]=1)[C:3]([F:6])([F:5])[F:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 130 °C
Procedure
The mixture of 1.86 g of 3-(pentafluoroethyl)-1H-pyrazole and 0.60 g of paraformaldehyde was stirred at 130° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered. The filtrate was concentrated under reduced pressure to obtain 1.98 g of 3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol.
Workup
- temperatureAfter the reaction mixture was cooled to room temperature
- filtrationThe mixture was filtered
- concentrationThe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-43c92962c4fa4633a2ee2347d7f766f7
- Source dataset
- uspto-grants-2009_06
- Patent number
- US07541374B2
Reaction notes
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