反应详情

温度

0 °C

9.30 g of 3-(pentafluoroethyl)-1H-pyrazole was suspended to 90 ml of water, and 6.0 g of 50% aqueous solution of sodium hydroxide was added to the suspension. The mixture was cooled to 0° C., then 8.79 g of bromine was added to the mixture, followed by stirring at room temperature for 7 hours. The reaction mixture was extracted by ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium salfate, filtered, and concentrated under reduced pressure to obtain 13.72 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole.

1. additionwas added to the suspension
2. extractionThe reaction mixture was extracted by ethyl acetate
3. washThe organic layer was washed with water
4. dry with materialdried over anhydrous magnesium salfate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure