Formaldehyde → 4-(trifluoromethyl)-1H-imidazole-1-ylmethanol

HRID 1983047Notes

Reaction equation

HRID 1983047 reaction equation
[F:1][C:2]([F:9])([F:8])[C:3]1[N:4]=[CH:5][NH:6][CH:7]=1.[CH2:10]=[O:11]>CC(C)=O>[F:1][C:2]([F:9])([F:8])[C:3]1[N:4]=[CH:5][N:6]([CH2:10][OH:11])[CH:7]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 178418921HCID 178418921, compound

Product 1

HCID 231491644-(trifluoromethyl)-1H-imidazole-1-ylmethanolYield 98.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
140 °C

Procedure

The mixture of 1.80 g of 4-(trifluoromethyl)-1H-imidazole, 0.78 g of paraformaldehyde was stirred at 140° C. for 4 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered, and then the filtrate was concentrated under reduced pressure to obtain 2.16 g of 4-(trifluoromethyl)-1H-imidazole-1-ylmethanol.

Workup

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-54bcd229106b40e9a7dfced4cd582c5d
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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