HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1983047Generated: November 1, 2026
Formaldehyde → 4-(trifluoromethyl)-1H-imidazole-1-ylmethanol
https://huagongshe.com/reaction/1983047
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | HCID 178418921 | HCID 178418921 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(trifluoromethyl)-1H-imidazole-1-ylmethanol | HCID 23149164 | 98.3% |
Reaction Steps
The mixture of 1.80 g of 4-(trifluoromethyl)-1H-imidazole, 0.78 g of paraformaldehyde was stirred at 140° C. for 4 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered, and then the filtrate was concentrated under reduced pressure to obtain 2.16 g of 4-(trifluoromethyl)-1H-imidazole-1-ylmethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07541374B2 |
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| Source dataset | uspto-grants-2009_06 |
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| ORD ID | ord-54bcd229106b40e9a7dfced4cd582c5d |
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| Source note | uspto-grants-2009_06 |
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