Thionyl Chloride → 860807-68-7

HRID 1983049Notes

Reaction equation

HRID 1983049 reaction equation
[C:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]([CH2:12]O)[CH:4]=1)#[N:2].S(Cl)([Cl:16])=O>ClCCl>[Cl:16][CH2:12][N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:3]([C:1]#[N:2])=[CH:4]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 23149206HCID 23149206, compound

Product 1

HCID 23149144860807-68-7

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.69 g of 3-cyano-1H-indole-1-ylmethanol was dissolved to 30 ml of dichloromethane. 1.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to obtain 1.70 g of 1-(chloromethyl)-3-cyano-1H-indole.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-560711731de94df7b3ec5ecf1e48f2dd
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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