2-Methoxynicotinic acid → HCID 67215639, compound

HRID 1983172Notes

Reaction equation

HRID 1983172 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([NH:15][NH2:16])=[O:14].[CH3:17][O:18][C:19]1[N:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21](O)=O>>[CH3:17][O:18][C:19]1[C:20]([C:21]2[O:14][C:13]([C:3]3[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)=[N:5][O:6][C:2]=3[CH3:1])=[N:15][N:16]=2)=[CH:24][CH:25]=[CH:26][N:27]=1

Participants

3

Reactant 2

HCID 7080932-Methoxynicotinic acidHCID 7279245-Methyl-3-phenyl-4-isoxazolecarbohydrazide

Product 1

HCID 67215639HCID 67215639, compoundYield 53%

Procedure

As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (200 mg, 0.92 mmol) was converted using 2-methoxynicotinic acid instead of o-toluic acid to the title compound (SiO2, heptane:ethyl acetate:dichloromethane=60:20:20 to 0:80:20, 163 mg, 53%) which was obtained as a white solid. MS: m/e=335.3 [M+H]+.

Sources & evidence

ORD record
ord-a5d87f7a72aa4626830853a47b98b99e
Source dataset
uspto-grants-2009_06
Patent number
US07541372B2

Reaction notes

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