Thiomorpholine → HCID 67215239, compound

HRID 1983197Notes

Reaction equation

HRID 1983197 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:13]3[C:14]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[N:15][O:16][C:17]=3[CH3:18])=[N:11][N:12]=2)=[CH:4][N:3]=1.[NH:25]1[CH2:30][CH2:29][S:28][CH2:27][CH2:26]1>>[CH3:18][C:17]1[O:16][N:15]=[C:14]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]=1[C:10]1[O:9][C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:25]3[CH2:30][CH2:29][S:28][CH2:27][CH2:26]3)=[N:3][CH:4]=2)=[N:12][N:11]=1

Participants

3

Reactant 2

HCID 67164ThiomorpholineHCID 86613584HCID 86613584, compound

Product 1

HCID 67215239HCID 67215239, compoundYield 59%

Procedure

As described for example 136b, 2-chloro-5-[5-(5-methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazol-2-yl]-pyridine (400 mg, 1.18 mmol) was converted using thiomorpholine instead of morpholine to the title compound (126 mg, 59%) which was obtained as an off-white solid. MS: m/e=406.3 [M+H]+.

Sources & evidence

ORD record
ord-4d2a9fdf7dc14c9185291307c94d41b6
Source dataset
uspto-grants-2009_06
Patent number
US07541372B2

Reaction notes

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